we will cover p 23-28 once we talk about neurons

dose-response relationship

2 types of dose-response curves

potency

efficacy or effectiveness

median effective dose  (ED50)

lethal dose (LD50)

therapeutic index (LD50/ED50)

safety margin

variability in individual response

subthreshold dose

threshold dose

slope of dose -response curve

maximum effect peak or plateau

safety margin

things that can change the dose-response relationship

1)Drug - Drug Interactions (example?)

    additive interaction

    potentiating interaction

    synergistic interaction

    anatagonistic interaction

    alteration of side effects

2)Drug- Food Interactions (example?)

3) tolerance (p. 21-22)

        metabolic tolerance

        cellular-adaptive or pharmacodynamic or tissue tolerance

        behavioral tolerance or behavioral conditioning

        cross-tolerance

tolerance vs dependence

        physical dependence

            abstinence or withdrawal syndrome

            cross-dependence

        psychological dependence

            craving and compulsive use

other factors affecting response to drug

therapeutic effect vs "side effects"

adverse reactions

    allergic reactions/hypersenstivity

        anaphylaxis

    indiosyncratic responses

    toxic effects

    signs of drug distress

dangers of street drugs

placebo

placebo effects

Drug Names (p.3)
    chemical

    generic

    brand

    street/popular

Generic/Brand Name equivalence

    chemical equivalence

    bioequivalence and bioavailability

Physician's Desk Reference (PDR)