Sexual Differentiation
describe the relationship of the hypothalamus to the anterior
pituitary (how does it control the anterior pituitary?)
draw the chain of command (hypothalamus, anterior pituitary,
ovaries or testes and write in what kind of hormones are released
at each level (related to sexuality). Draw in the negative
feedback loops as well. What actually provides the feedback
signal?
What is meant when we say sex hormones have
ORGANIZING/developmental effects?
How does a sex chromosome play a role in the very first step of
sexual differentiation? (be specific) What is the gene called?
Beyond that first step, what has the strongest influence on the
remainder of sexual differentiation? (be specific)
describe how one comes to have either male (wolffian) and/or
female (mullerian) ducts
what is mullerian inhibiting hormone?
describe how one comes to have either male or female genitalia (or
something in between)
what is dihydrotestosterone?
what do we mean by a sensitive period (or critical period)?
can you predict the effects of alterations in the early hormone
environment (e.g. giving females androgens, removing androgens
from males, giving huge doses of estrogens)
by what mechanism does testosterone appear to "masculinize" the
brain of rats (and probably some other species too)
what is the role of alpha-fetoprotein (in this situation)
what is the sexually dimorphic nucleus? what is the analgous
structure in humans?
give several behavioral and anatomical examples of how "sexual"
differentiation affects more than sexual behavior and orientation
contrast "activational" effects (when they most often occur, how
lasting they are) with organizational/developmental effects
what is likely to happen to sexual differentation (and what might
happen in terms of gender identity later on) is these cases?
XY male with a mutated or missing SRY gene
XX female who receive a SRY through a crossing over in here
father's genetic material
XY male who lacks the gene which produces androgen receptors
XX female who is exposed to somewhat higher than normal levels of
androgens in utero
XX female who is exposed to very high levels of androgens in utero
XX female who is exposed to abnormally high levels of estrogens in
utero
XY male with a defective gene for the enzyme 5-alpha-reductase
what biological factors would continue to influence the
gender identity of the male child raised as a female after
accidental removal of penis during circumcision?
what research findings support a role for each of the following in
homosexual orientation:
genetics
early hormone (but not adult hormone) levels
stress during gestation having older brothers
brain differences
Memory
What makes the brain susceptible to closed head injury even when there is no skull fracture?What is the difference between retrograde amnesia and anterograde
amnesia?
Be familiar with the case of HM and what memory functions were
lost and which remained after the surgery to treat his epilepsy
What is the difference between implicit and explicit memories (or
the related terms procedural vs declarative memories)What are
semantic memories? Episodic memories?
Contrast 2 other well known memory disorders (Korsakoff's
syndrome and Alzheimer's disease) with the amnesia produce by
hippocampal damage.
what parts of the brain are involved and how
what aspects of memory are affected
who suffers from the problem
what is known about the cause(s)
what do these problems share in common
Psychological Disorders
what data suggest a role of genetics in the occurrence of
schizophrenia?
what is the dopamine theory? What evidence supports this theory?
what is the neurodevelopmental theory of schizophrenia? What
evidence supports this theory?
What are some of the prenatal or neonatal factors associated with
increased risk of schizophrenia?
What is the season of birth effect? What factor does it suggest
might play a role in the causation of schizophrenia?
What are some of the ways in which brain anatomy or brain
activity differ from normal in schizophrenics?
Various types of research/evidence supporting a biological
contribution to the occurrance of depression
Give examples of at least 5 different kinds of research findings
relating biological factors to mood/mood disorders.
What evidence suggests a role for genetics in depression?
What other biological factors can play a role in mood disorders?
What does the Monoamine theory of mood/depression propose?
What are the 3 main categories of antidepressants, an example of
each, and how does each work?
In what way is their effect on brain chemistry similar?
What changes in brain anatomy or functioning are associated with
mood disorders?
What does the neuroplasticity/neurogenesis theory of depression
propose?
If we have time we might also get to the following:
What differences in brain have been linked to anxiety/fear?
What neurotransmitter has been most strongly linked to anxiety
disorders?
How do antianxiety medications affect this transmitter?
Some antianxiety medications work on a different transmitter.
Which and how? (are they agonists or antagonists?)
What is Urbach-Wiethe disease and its affect on anxiety?
What is known about the biological influences on OCD?
How about Tourette's syndrome?
What medications are used to treat each of these and what
neurotransmitter do these meds influence?