Notes to Prepare for Jeopardy and Test 1
You do not have to reproduce your notes from class to answer the questions below - you can simply, in your own words, explain what a term refers to or provide a brief answer to each question - to show you know enough that you could respond correctly if you were asked the same question on our test.
What happens (or where is the drug) during each of the following steps?
Administration
Absorption
Name a factor that can affect speed or effectiveness of absorption:
Distribution
Name a factor that can
affect distribution:
Action
What will be the site of drug action for most of the drugs we discuss?
Termination of Effect/Elimination
Name a factor that can affect the speed or effectiveness of drug elimination:
Route |
Pros |
Cons |
Oral |
|
|
Inhalation |
|
|
Injection |
|
|
What are some other routes and why might they be used?
3 types of drug names a particular drug may be called by:
Briefly explain the following from our discussion
of the
dose response curves:
Threshold dose (TD):
Effective dose 50 (ED50):
Maximal effect (MAX):
Lethal dose 1 (LD!):
What other dose-response information
helps us evaluate the safety
of a
drug?
Drugs are often contrasted on their POTENCY and on their EFFECTIVENESS.
Which of the following is an example of a difference in potency ________
Which is a difference is effectiveness _______
A. Taking 400 mg. of ibuprofen produces the same degree of arthritis pain and inflammation relief as would taking 150 mg. of ketoprofen.
B. The severe pain experienced by burn victims is barely relieved at all by taking even high doses of aspirin but can be dramatically reduced by taking morphine.
Explain these types of adverse reactions to drugs:
Hypersensitivity:
Most severe example of hypersensitivity:
Idiosyncratic response:
Contrast these 2 types of drug interactions:
Synergistic
Antagonistic
Briefly describe the 3 different explanations of why you become tolerant to a drug.
1)
2)
3)
If a drug affects this part of the brain |
it=s likely to affect your functioning in this way |
medulla |
|
limbic system |
|
cerebellum |
|
hypothalamus |
|
reticular
formation |
|
Neurotransmitter |
Best known functions |
Norepinephrine |
|
Acetylcholine |
|
Serotonin (5HT) |
|
Dopamine |
|
Endorphins |
|
GABA |
|
Can you explain these terms:
first pass metabolism
half-life
agonist
reuptake
Draw and label these main parts of a neuron
(dendrites, cell
body, axon, axon terminals)
Draw and label these main parts of a synapse
(presynaptic axon
terminal, synaptic vesicles, synaptic cleft or gap, postsynaptic
membrane with
receptor sites)