Notes to Prepare for Jeopardy and Test 1

 

You do not have to reproduce your notes from class to answer the questions below - you can simply, in your own words, explain what a term refers to or provide a brief answer to each question - to show you know enough that you could respond correctly if you were asked the same question on our test.

 

What is pharmacokinetics?                                             What is pharmacodynamics?

 

What happens (or where is the drug) during each of the following  steps?

 

Administration

 

Absorption

 

Name a factor that can affect speed or effectiveness of absorption:

 

Distribution

 

Name a factor that can affect speed of distribution:

Action

 

What will be the site of drug action for most of the drugs we discuss?

 

Termination of Effect/Elimination

 

Name a factor that can affect the speed or effectiveness of drug elimination:

 

 

Route

 

Pros

 

Cons

 

Oral

 

 

 

 

 

Inhalation

 

 

 

 

 

Injection

 

 

 

 

 

What are some other routes and why might they be used?

 

 

 

3 types of Adrug names@ a particular drug may be called by:

 

 

 

 

 

Briefly explain the following from our discussion of the dose response relationship:

 

Threshold dose (TD):

 

 

Effective dose 50 (ED50):

 

 

Maximal effect (MAX):

 

 

What other Adose@ helps us evaluate the safety of a drug?

 

 

Drugs are often contrasted on their POTENCY and on their EFFECTIVENESS.

 

Which of the following is an example of a difference in potency ________

 

Which is a difference is effectiveness _______   

 

A. Taking 400 mg. of ibuprofen produces the same degree of arthritis pain and inflammation relief as would taking 150 mg. of ketoprofen.   

B. The severe pain experienced by burn victims is barely relieved at all by taking even high doses of aspirin but can be dramatically reduced by taking morphine.          

 

Explain these types of adverse reactions to drugs:

Hypersensitivity:

 

 

Most severe example of hypersensitivity:

 

Idiosyncratic response:

 

 

Contrast these 2 types of drug interactions:                   

Synergistic                                                                          Antagonistic

 

 

Briefly describe the 3 different explanations of why you become tolerant to a drug.

1)

 

2)

 

 

3)

 

 

If a drug affects this part of the brain

 

it=s likely to affect your functioning in this way

 

medulla

 

 

 

limbic system

 

 

 

cerebellum

 

 

 

hypothalamus

 

 

 

reticular formation

 

 

 

 

Neurotransmitter

 

Best known functions

 

Norepinephrine

 

 

 

Acetylcholine

 

 

 

Serotonin (5HT)

 

 

 

Dopamine

 

 

 

Endorphins

 

 

 

GABA

 

 

 

Can you explain these terms:

 

first pass metabolism

 

 

half-life

 

 

agonist

 

 

reuptake

 

 

Draw and label the main parts of a neuron (dendrites, cell body, axon, axon terminals)

 

 

 

Draw and label the main parts of a synapse (presynaptic axon terminal, synaptic vesicles, synaptic cleft or gap, postsynaptic membrane with receptor sites)