·
Spinal Cord
Vocabulary
·
Foramen magnum
·
Segments of cord
·
Conus medullaris
·
Cauda equina
·
Filum terminale
·
Cervical and
lumbar enlargements
·
Spinal reflexes
·
White matter
“columns”
·
Long “tracts” of
cord
·
Gray matter “dorsal,
ventral & lateral horns”
·
Dorsal and
ventral roots
·
Dorsal root
ganglia
·
Vertebrae & intervertebral disks
·
Intervertebral foramina
·
Meninges of Cord
·
Spinal Roots and
Nerve
·
How Sensory Input
Enters Cord
·
Dermatomes
·
Ascending Tracts
or Pathways
·
“Afferent"
tracts carrying sensory input up cord from body to brain
·
Basic
Organization of Ascending Somatosensory Pathways
·
A series of 3
neurons is needed to get the message from body surface to cortex:
·
First-order
neuron: carries input from skin to CNS (dendrites are sensitive to external
stimulus, soma is in dorsal root ganglia, axon enters CNS & synapses on 2nd
neuron)
·
Second-order
neuron: axon of 2nd cell
crosses to the opposite side of CNS & carries input up to the thalamus. Also sends a branch to the reticular
formation to arouse us.
·
Third order
neuron: Thalamus neuron relays input to the cortex.
·
Key Pathways
Mediating Conscious Sensations
·
Dorsal
column pathway – discriminative (detailed, fine) touch, proprioception
(limb position/motion sense), & vibration. This tract is needed for us to feel & precisely
locate light touch & do 2 point discrimination, stereognosis
& graphesthesia.
·
Spinothalamic pathways – pain, temperature and gross touch
·
White Matter
Columns in Cord (see Fig. 8.13)
·
Dorsal Column
Pathway (Fig. 8.14)
·
Spinal Tracts
·
What happens if you suffer damage to or deterioration
of the dorsal
column pathway?
·
Irritation of Sensory Receptors
·
As sensory
receptors deteriorate, they may malfunction before they stop functioning
causing paresthesia or dysesthesia.
·
E.g. in “tabes dorsalis” shooting, lancinating, electrical-like or cramp-like pains occur, and
in peripheral neuropathy unpleasant abnormal tingling, burning, tightness,
& “pins & needles” paresthesias occur.
·
You’ve
experienced temporary paresthesias when your arm or
leg “falls asleep”; also one of the early signs of carpal tunnel syndrome
·
Sensory Ataxia
·
Gait (walking)
problems related to loss of proprioception following
degeneration of dorsal columns and/or dorsal roots.
·
Watches feet
while walking, feet tend to slap down; shows a “positive Romberg’s sign”
(person sways and is unsteady if asked to stand with eyes closed)
·
Some of the
causes:
·
Syphilis – “Tabes dorsalis”
·
Vitamin B-12
deficiency
·
Peripheral
neuropathy (e.g. as seen in diabetics and alcoholics)
·
Multiple sclerosis
·
Tabes Dorsalis (see study guide)
·
Astereognosis
·
Another symptom
of dorsal column damage
·
Without fine
discriminative touch person cannot identify objects or textures by touch
·
Example: Can
happen in MS if dorsal column loses its myelin
·
Spinothalamic Pathway
(Fig 8.15)
·
Pain, temperature
and gross touch
·
Pain Chemicals
·
What will happen to an individual who has irritation
of
or damage to the lateral spinothalamic pathway?
·
Have you had chicken
pox?
·
If so, about 20%
of you are likely to develop Shingles sometime later in your life.
·
Shingles (aka Herpes Zoster)
(1 million cases/yr in US)
·
After chicken pox
the virus (Varicella zoster) lies dormant in dorsal
root ganglia.
·
It may “re-activate”
if your immune system is weakened or stressed, or as you get older (most common
after 50-60).
·
The first sign is
tingling, burning or shooting pains, usually in a single unilateral dermatome.
·
A few days later
a pox-like painful rash develops in that dermatome, lasting 4-5 weeks.
·
Herpes Zoster or
Shingles
·
Treatment
·
Antiviral drugs
like acyclovir can shorten the attack & decrease complications if taken
when the first signs appear.
·
Antiinflammatory pain relievers may be necessary.
·
Zostrix (capsaicin) cream applied to unbroken skin also
relieves pain by decreasing the supply of Substance P in pain receptors.
·
Now
experimenting with boosting immunity with chicken pox vaccination.
·
Pain Perception
·
Recall the woman
whose pain responses were being tested in the video
·
Electrode
implanted in her calf, stimulating nerve of spinothalamic
pathway
·
She perceived the
pain as coming from her foot, not her calf
·
Referred Pain
– we often experience pain from organs as if it were coming from the surface of
body
·
The “Gate Control” for Pain
·
Ramachandran’s
Mirror Box Therapy for Phantom Limb Pain
·
Descending Pain
Suppression Pathway
·
Another disorder affecting the spinothalamic
pathway: Syringomyelia
·
Enlarged CSF
filled cavity within cervical spinal cord, most often associated with Chiari malformation (cerebellum bulging thru foramen
magnum)
·
Cavity compresses
and damages nearby
tissue (like hydrocephalus of cord)
·
“Cape
anesthesia”, loss of pain & temp sensation from hands, weakness if ventral
horns damaged
·
If severe,
operate on malformation or shunt.
·
Syringomyelia
·
MRI of Cavity